Clinical intelligence hub for longevity, geroscience and healthspan research.

Weekly clinic briefing added to the research vault. This item links to the full data-backed clinic report for doctor review and patient education.

Evidence: Human data. Published/updated: 2026-06-15.

Clinician note: Clinic briefing. Keep patient wording educational and avoid treatment recommendations unless reviewed by Dr Rob.

MOTS-c remains an active research topic because mitochondrial-derived peptides may connect metabolic stress, exercise biology and ageing pathways. Current patient-facing framing should stay cautious: interesting biology, not a clinical recommendation.

Evidence: Review. Published/updated: 2025-01-01.

Clinician note: Discuss only as emerging mitochondrial peptide science. Do not imply availability, suitability or clinical benefit.

GLP-1 receptor agonists are being discussed in longevity circles because of weight, metabolic and inflammatory mechanisms. The library should clearly separate approved medical uses from unproven longevity or microdosing claims.

Evidence: Human data. Published/updated: 2025-01-01.

Clinician note: State that any GLP-1 use is a medical decision requiring proper indication, monitoring and risk review.

Automated weekly educational research update for Hallmark Precision Health. PubMed selected sources: 1. Lysosomal Competence in Skeletal Muscle Aging: Autophagic Flux, Measurement Gaps, and Human Translation (Aging and disease) — https://pubmed.ncbi.nlm.nih.gov/42858326/ 2. THE AGING PURINOME: A PURINERGIC FRAMEWORK LINKING THE HALLMARKS OF AGING TO INFLAMMAGING (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42858859/ 3. Driver or Passenger? A Bradford Hill Framework for Aging-Associated lncRNAs (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42858860/ 4. Mitochondria Beyond Bioenergetics: Canonical and Non-Canonical Functions in Ischemic Stroke and Aging (Aging and disease) — https://pubmed.ncbi.nlm.nih.gov/42858325/ 5. GLP-1-based therapies in lung diseases (The European respiratory journal) — https://pubmed.ncbi.nlm.nih.gov/42860278/ 6. Clocks and steroids interaction across the life span (Journal of neuroendocrinology) — https://pubmed.ncbi.nlm.nih.gov/42860139/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - Facebook (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - Facebook (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxPYndaMUlmczVhQzNVUE1VQlFkaUhWUDh1MXlzVGpoNzBweFRiUGg2X0hPNnJqcVRfdGdtNm5YWGVDeWgwWTZuSmV5UHdYQlNkekNSM2FjcHhhaGxDSW9sNU0yNkVoQXBxMTZpcU9sZnpTdDZrekZFS2pHMXdLSWxfY1RsaE5vSjR0VVZDcFNQU1dqZlYxT09Ea3dGNXpCQW8tMjl2RkJPeUpLYnNUc1JDZVc0cTFDalgzZTBpZTI4aVZCWndfVF9NSEo3cS1tU1Y5NzBnVmUwTTVkT0R6?oc=5 3. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 4. Global Leaders in Geroscience Convene for Biomarkers of Aging (Lifespan.io) — https://lifespan.io/global-leaders-in-geroscience-convene-for-biomarkers-of-aging/ 5. FDA Leaders Name Longevity a Priority at ARDD (Lifespan.io) — https://lifespan.io/fda-leaders-name-longevity-a-priority-at-ardd/ 6. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 7. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 8. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-10-12.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial (Nature medicine) — https://pubmed.ncbi.nlm.nih.gov/42823485/ 2. Delivery systems for bioactive ingredients in functional foods support healthy aging: Advances and Challenges (The Journal of nutrition) — https://pubmed.ncbi.nlm.nih.gov/42829190/ 3. Does ageing increase vulnerability to hypoglycaemia and hyperglycaemia? A systematic review of physiological and cognitive responses (Diabetes research and clinical practice) — https://pubmed.ncbi.nlm.nih.gov/42829186/ 4. Beyond Skin Laxity: GLP-1 Receptor Agonist-Induced Lean Mass Depletion and Surgical Tissue Quality in Aesthetic Surgery: A Narrative Review (Aesthetic surgery journal. Open forum) — https://pubmed.ncbi.nlm.nih.gov/42820120/ 5. The therapeutic potential of transposable element activity modulation (EMBO molecular medicine) — https://pubmed.ncbi.nlm.nih.gov/42829380/ 6. REST in the Central Nervous System: Context-Dependent Regulation of Neuronal Homeostasis and Disease (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience) — https://pubmed.ncbi.nlm.nih.gov/42827376/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxPYndaMUlmczVhQzNVUE1VQlFkaUhWUDh1MXlzVGpoNzBweFRiUGg2X0hPNnJqcVRfdGdtNm5YWGVDeWgwWTZuSmV5UHdYQlNkekNSM2FjcHhhaGxDSW9sNU0yNkVoQXBxMTZpcU9sZnpTdDZrekZFS2pHMXdLSWxfY1RsaE5vSjR0VVZDcFNQU1dqZlYxT09Ea3dGNXpCQW8tMjl2RkJPeUpLYnNUc1JDZVc0cTFDalgzZTBpZTI4aVZCWndfVF9NSEo3cS1tU1Y5NzBnVmUwTTVkT0R6?oc=5 3. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 4. Global Leaders in Geroscience Convene for Biomarkers of Aging (Lifespan.io) — https://lifespan.io/global-leaders-in-geroscience-convene-for-biomarkers-of-aging/ 5. FDA Leaders Name Longevity a Priority at ARDD (Lifespan.io) — https://lifespan.io/fda-leaders-name-longevity-a-priority-at-ardd/ 6. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 7. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 8. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.wordpress.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Commentary. Published/updated: 2026-10-05.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. Nanoparticle-Based Tools to Study Hallmarks of Aging at the Molecular Level (International journal of nanomedicine) — https://pubmed.ncbi.nlm.nih.gov/42801224/ 2. Alzheimer's Disease: From Molecular Pathogenesis to Disease-Modifying Therapies and Clinical Implementation in Aging Populations (Clinical interventions in aging) — https://pubmed.ncbi.nlm.nih.gov/42801246/ 3. Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential (Reproductive medicine and biology) — https://pubmed.ncbi.nlm.nih.gov/42801052/ 4. Neuroenergetic Flexibility in the Aging Brain: Cellular Mechanisms and Diet-Induced Metabolic Switching (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42800643/ 5. Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol (The Journal of frailty & aging) — https://pubmed.ncbi.nlm.nih.gov/42801476/ 6. DEED-FRAIL trial: A cluster-randomized trial of a frailty-oriented multicomponent ED discharge intervention for older adults with geriatric vulnerability and acute heart failure (European journal of internal medicine) — https://pubmed.ncbi.nlm.nih.gov/42800747/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 3. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 4. Clearing Damaged Mitochondria to Fight Skin Photoaging (Lifespan.io) — https://lifespan.io/clearing-damaged-mitochondria-to-fight-skin-photoaging/ 5. Lung Fibrosis Drug Lowers Biological Age Estimates (Lifespan.io) — https://lifespan.io/lung-fibrosis-drug-lowers-biological-age-estimates/ 6. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 7. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 8. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-09-28.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. NAD(+)-sirtuin-mitochondrial quality control in lens epithelial cells: a candidate modulatory network in crystalline lens aging (Experimental eye research) — https://pubmed.ncbi.nlm.nih.gov/42764115/ 2. Panvascular Aging: The Pioneer Organ Hypothesis, Research Models and Future Directions (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42764106/ 3. A Matter of Balance: Heme Oxygenase-1 at the Crossroads of Healthy and Pathological Aging (Archives of biochemistry and biophysics) — https://pubmed.ncbi.nlm.nih.gov/42764089/ 4. Targeting the cardiohepatic-metabolic axis: GLP-1-based and incretin multi-agonist therapies in MASH (British journal of clinical pharmacology) — https://pubmed.ncbi.nlm.nih.gov/42755225/ 5. CSenescence-associated-secretory phenotype proteins and inflammatory pathways are involved in psychosis: A transdiagnostic study using the Human Connectome Project for early psychosis (HCP-EP) data (Brain, behavior, and immunity) — https://pubmed.ncbi.nlm.nih.gov/42764136/ 6. The role of air quality and pollution in obstructive sleep apnea: insights from recent studies (Expert review of respiratory medicine) — https://pubmed.ncbi.nlm.nih.gov/42764180/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 3. The bioavailability of compounded and generic rapamycin in normative aging individuals: A retrospective study and review with clinical implications - medRxiv (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMidEFVX3lxTFA1RFVTMmRIS1pwM2ZXTFVXdkxaNzdRcnk3ejFQbGFjLWdERHpBTG83b3FEZ3BjNmFLblN2cVlPRjc4TjJCY05Pbk5Gcnk3cHBkaGJMd1dkbU1sSzVzdnBYSFZ2dkhpR3hSN3NXeEV6a1JnZ01u?oc=5 4. Clearing Damaged Mitochondria to Fight Skin Photoaging (Lifespan.io) — https://lifespan.io/clearing-damaged-mitochondria-to-fight-skin-photoaging/ 5. Your Personal Longevity Assistant: Evipedia Grok Bot (Lifespan.io) — https://lifespan.io/your-personal-longevity-assistant-evipedia-grok-bot/ 6. From World Cup Champions to Longevity Champions (Lifespan.io) — https://lifespan.io/from-world-cup-champions-to-longevity-champions/ 7. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 8. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-09-21.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. Resveratrol engages SIRT1/AMPK networks to restore BDNF signaling, autophagy, and mitochondrial function in age-related cognitive decline: A geroscience perspective (Progress in neuro-psychopharmacology & biological psychiatry) — https://pubmed.ncbi.nlm.nih.gov/42731586/ 2. Epigenetic clocks and accelerated biological aging in people living with HIV: Emerging mechanisms and clinical implications (Experimental gerontology) — https://pubmed.ncbi.nlm.nih.gov/42731644/ 3. The Expanding Role of GLP-1 Receptor Agonists and Dual GIP/GLP-1 Agonists in Dermatology: From Immunometabolism to Clinical Practice (Dermatology and therapy) — https://pubmed.ncbi.nlm.nih.gov/42728528/ 4. Artificial Intelligence-Related Voice and Speech Biomarkers of Alzheimer's Disease: A Systematic Review (Journal of voice : official journal of the Voice Foundation) — https://pubmed.ncbi.nlm.nih.gov/42731970/ 5. The effects of physical activity on female fertility: a narrative review (Journal of assisted reproduction and genetics) — https://pubmed.ncbi.nlm.nih.gov/42730950/ 6. A Review of Senescence-Associated Secretory Phenotype-Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy (Cancer reports (Hoboken, N.J.)) — https://pubmed.ncbi.nlm.nih.gov/42732921/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 3. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 4. Your Personal Longevity Assistant: Evipedia Grok Bot (Lifespan.io) — https://lifespan.io/your-personal-longevity-assistant-evipedia-grok-bot/ 5. From World Cup Champions to Longevity Champions (Lifespan.io) — https://lifespan.io/from-world-cup-champions-to-longevity-champions/ 6. Comparing the Responsiveness of Epigenetic Aging Biomarkers (Lifespan.io) — https://lifespan.io/comparing-the-responsiveness-of-epigenetic-aging-biomarkers/ 7. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 8. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-09-14.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. From Target Engagement to Translational Disconnect: A Systematic Review and Narrative Synthesis of Direct Tau-Targeted Clinical Trials in Alzheimer's Disease and Primary Tauopathies (Pharmacological research) — https://pubmed.ncbi.nlm.nih.gov/42702342/ 2. Risk factors for frailty in aging: from sex and gender and genetic determinants to the exposome (Journal of toxicology and environmental health. Part B, Critical reviews) — https://pubmed.ncbi.nlm.nih.gov/42702586/ 3. Experience-Dependent Plasticity of Large-Scale Brain Networks in Aging: How Different Training Modalities Shape Neural Connectivity (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42702295/ 4. Vascular Frailty: A New Paradigm Linking Biological Aging, Gero-Nephrology, and Vascular Medicine (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42702293/ 5. Breaking the Self-Reinforcing Cycle of Aging: Biomaterial Strategies for Aged Bone Regeneration (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42700868/ 6. Use of fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in Asians with type 2 diabetes (Primary care diabetes) — https://pubmed.ncbi.nlm.nih.gov/42697752/ External longevity news sources: 1. In dogs, two clinical trials of antiaging drugs are underway: One for rapamycin and one for LOY-002, a more mysterious medicine. If studies show that these drugs lengthen a dog’s healthy lifespan, there would be additional support for their use in humans. http - facebook.com (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMi3AFBVV95cUxOME1GUTkzLXZ2QW1sU1BTUTNPSjlGa3JUWlhralVIOElHc253aXhxUURWZWJiY1lTQzZNSmpjYUVnVTJIajEySm5BcEhITl9aU2QyTktWVEc5TEI0dTAyc2p0eXF2S2R4QmlJUGVmUWpfWE96UUFqazdBdGJXSGVWM0J2b2ZQRVVFc2ZOekkwX3k1cU5oT0cwTU8xZEgya0RpQ1JJeXZ2a05pZGtyQ05Ya1pfLW5NOWVOempCQUJOWmtUX2ZwUDhyYnlaZmZHaUdsSC1iNEVoZzNrT1hu?oc=5 2. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 3. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 4. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 5. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 6. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-09-07.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. Effects of circle dance (CircleCare) on the physical and mental health of women caregivers of older adults with Alzheimer's disease: a randomized controlled study (Geriatric nursing (New York, N.Y.)) — https://pubmed.ncbi.nlm.nih.gov/42667878/ 2. Therapeutic Mechanisms of Resmetirom and Semaglutide in MASLD/MASH: A Review of Inflammatory and Fibrotic Metabolites (Metabolites) — https://pubmed.ncbi.nlm.nih.gov/42646322/ 3. Living Beyond Our Evolutionary Warranty: Why Non-Communicable Diseases May Be The Inevitable Costs of an Extended Lifespan (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42668122/ 4. Multiscale structure-property relationships in additively manufactured load-bearing metallic implants (Biomaterials advances) — https://pubmed.ncbi.nlm.nih.gov/42667697/ 5. Microplastic and nanoplastic interactions with per- and polyfluoroalkyl substances (PFAS) in soils: a critical review of main findings and knowledge gaps (Environmental geochemistry and health) — https://pubmed.ncbi.nlm.nih.gov/42667455/ 6. Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities (Journal of translational autoimmunity) — https://pubmed.ncbi.nlm.nih.gov/42668582/ External longevity news sources: 1. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 2. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 3. The bioavailability of compounded and generic rapamycin in normative aging individuals: A retrospective study and review with clinical implications - medRxiv (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMidEFVX3lxTFA1RFVTMmRIS1pwM2ZXTFVXdkxaNzdRcnk3ejFQbGFjLWdERHpBTG83b3FEZ3BjNmFLblN2cVlPRjc4TjJCY05Pbk5Gcnk3cHBkaGJMd1dkbU1sSzVzdnBYSFZ2dkhpR3hSN3NXeEV6a1JnZ01u?oc=5 4. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 5. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 6. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ 7. How Senescence Spreads Between Brain Cells (Lifespan.io) — https://lifespan.io/how-senescence-spreads-between-brain-cells/ 8. A Drug Combination Fights Both Senescence and Cancer (Lifespan.io) — https://lifespan.io/a-drug-combination-fights-both-senescence-and-cancer/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Commentary. Published/updated: 2026-08-31.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. Exercise and p21 Signaling in Central Nervous System Aging and Senescence: A Context- and Dose-Dependent Relationship (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42632465/ 2. GLP-1 receptor agonist therapy and skeletal muscle: A narrative review synthesizing adult evidence with implications for older adults (JAR life) — https://pubmed.ncbi.nlm.nih.gov/42633386/ 3. Nutrition and microbiota in ocular surface and dry eye disease (Archivos de la Sociedad Espanola de Oftalmologia) — https://pubmed.ncbi.nlm.nih.gov/42633880/ 4. Protective effect and mechanism of SIRT1 under stress-induced vascular senescence (Open life sciences) — https://pubmed.ncbi.nlm.nih.gov/42633089/ 5. Ergothioneine: from biosynthesis to sustainable biomanufacturing and health applications (Biotechnology advances) — https://pubmed.ncbi.nlm.nih.gov/42632602/ 6. Scientometric analysis of mycosporine-like amino acids from 1989 to 2025: Current trends and applications (Bioresource technology) — https://pubmed.ncbi.nlm.nih.gov/42632472/ External longevity news sources: 1. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 2. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 3. The bioavailability of compounded and generic rapamycin in normative aging individuals: A retrospective study and review with clinical implications - medRxiv (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMidEFVX3lxTFA1RFVTMmRIS1pwM2ZXTFVXdkxaNzdRcnk3ejFQbGFjLWdERHpBTG83b3FEZ3BjNmFLblN2cVlPRjc4TjJCY05Pbk5Gcnk3cHBkaGJMd1dkbU1sSzVzdnBYSFZ2dkhpR3hSN3NXeEV6a1JnZ01u?oc=5 4. Why Affecting Aging in Complex Organisms Is So Hard (Lifespan.io) — https://lifespan.io/why-affecting-aging-in-complex-organisms-is-so-hard/ 5. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 6. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 7. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ 8. The Thymus Hormone Thymulin Reduces Inflammaging in Mice (Lifespan.io) — https://lifespan.io/the-thymus-hormone-thymulin-reduces-inflammaging-in-mice/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-08-24.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.

Automated weekly educational research update for Dr Rob Health. PubMed selected sources: 1. The microbiome in human skin aging (FEBS letters) — https://pubmed.ncbi.nlm.nih.gov/42603099/ 2. Aging's Competing Paradigms: Another Decade of Investigation into Damage-Driven versus Programmed Theories (Ageing research reviews) — https://pubmed.ncbi.nlm.nih.gov/42604639/ 3. Oxidative Stress in Female Ovarian Aging and Progress in Chinese Medicine Therapy (Chinese journal of integrative medicine) — https://pubmed.ncbi.nlm.nih.gov/42603250/ 4. Anti-Obesity Medications in Longevity and Aesthetic Medicine (Journal of clinical medicine) — https://pubmed.ncbi.nlm.nih.gov/42590128/ 5. CT-based prediction of hematoma expansion and adverse outcomes after intracerebral hemorrhage: evidence appraisal, artificial intelligence translation, and GeroScience perspectives (GeroScience) — https://pubmed.ncbi.nlm.nih.gov/42601546/ 6. Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy (EBioMedicine) — https://pubmed.ncbi.nlm.nih.gov/42603515/ External longevity news sources: 1. UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMirAFBVV95cUxNVWdwNjhuMUQxZnNmT3BzVVRnTEJxYnJlaVFNX1B1Q0NySnhaYWdwMloxdGRuZ3VoN0dnaS1DVDF0NlJJMWpRemtBSXhDUDg5Y1ZkOTBMRFp3by1jSk5EZmRBRElhNTJPUWFMbjYtOWtabnlWU0JrM2tMaUhsamZJZTZNVzBROWg0clJZVzJERHB4a3VrYk5OQVVqZVgtVVNOclZNVnJ2V3pNMFdl?oc=5 2. Rapamycin’s Effects on Human Aging Explored in New Study - Newsweek (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMieEFVX3lxTE5MNnZFcUY1bmVLTm80eC05T2FLRHg0QnZuN1ZpQjBGcXNpX0U5RFNSOVZEZXpXOTdXMDQ4X1hvcmxSRFNSX2RxUV9rX2liX2xyR1hWNUdyT2RLSDN3d3J1UTdpaGpEZGt0WUI4TTJKaGZrTU5SZFk1Mg?oc=5 3. The bioavailability of compounded and generic rapamycin in normative aging individuals: A retrospective study and review with clinical implications - medRxiv (Rapamycin Longevity News) — https://news.google.com/rss/articles/CBMidEFVX3lxTFA1RFVTMmRIS1pwM2ZXTFVXdkxaNzdRcnk3ejFQbGFjLWdERHpBTG83b3FEZ3BjNmFLblN2cVlPRjc4TjJCY05Pbk5Gcnk3cHBkaGJMd1dkbU1sSzVzdnBYSFZ2dkhpR3hSN3NXeEV6a1JnZ01u?oc=5 4. Why Affecting Aging in Complex Organisms Is So Hard (Lifespan.io) — https://lifespan.io/why-affecting-aging-in-complex-organisms-is-so-hard/ 5. 22y Younger Biological Age: Supplements, Diet (Blood Test #2 in 2025) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/22/22y-younger-biological-age-supplements-diet-blood-test-2-in-2025/ 6. Dave Pascoe Presents His Blood Test Results: Biological Age, RDW (Part I) (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/20/dave-pascoe-presents-his-blood-test-results-biological-age-rdw-part-i/ 7. 22y Younger Biological Age: Full Lab Results And Analysis (Michael Lustgarten, PhD) — https://michaellustgarten.com/2025/04/18/22y-younger-biological-age-full-lab-results-and-analysis/ 8. The Thymus Hormone Thymulin Reduces Inflammaging in Mice (Lifespan.io) — https://lifespan.io/the-thymus-hormone-thymulin-reduces-inflammaging-in-mice/ Some source feeds could not be read this week and should be checked manually: The Regenerative Medicine Foundation: fetch failed.

Evidence: Review. Published/updated: 2026-08-17.

Clinician note: Automated educational weekly source list. Dr Rob should review clinical wording before using any item for individual patient guidance.